Tables

From Previous Article: Treatment of Infections in Patients with Cystic Fibrosis by Lisa Saiman, MD, Columbia University, New York City [Infect Med 10(7):37-43, 1993]

Table I - Anti-Pseudomonal Antibiotics*

Antimicrobial	Dosage/route	Comments
Ticarcillin	250-400mg/kg/day Na+ load/ K+ wasting (max dose 24g/day) div q4h to q6h, IV
Ticarcillin	Same as ticarcillin	S. aureus inhibited clavulanate
Piperacillin	Up to 500mg/kg/day Less Na+ load;	hepatitis, div q6h, IV neutropenia
Ceftazidime	200mg/kg/day	Most active cephalosporin (max dose 8g) against Pseudomonas div q6h, IV
Imipenem/cilastatin	60-90mg/kg/day div q6h, IV
Aztreonam	200mg/kg/day div q6h, IV
Tobramycin	8-12mg/kg/day Peak 10ug/mL div q8h, IV Trough <2ug/mL 300 or 600mg q8h	Ultrasonic nebulizer aerosol
Gentamicin Tobramycin		more active
Amikacin Tobramycin		more active
Ciprofloxacin	500-750mg q12h	Reports of tooth staining oral in very young infants58 400mg q12h, IV

*Doses based on published studies

Table II - Antipseudomonal Drug Pairs Used in Synergy Studies*

Antimicrobial	Dosage/route	Comments
Ticarcillin/clavulanate	(8 to 64ug/mL) + Tobramycin (1 to 8ug/mL)
Ticarcillin/clavulanate	(8 to 64ug/mL) + Ciprofloxacin (0.5 to 16ug/mL)
Piperacillin	(8 to 64ug/mL) + Tobramycin (1 to 8ug/mL)
Piperacillin	(8 to 64ug/mL) + Ciprofloxacin (0.25 to 4ug/mL)
Ceftazidime	(4 to 128ug/mL) + Tobramycin (1 to 8ug/mL)
Ceftazidime	(4 to 128ug/mL) + Amikacin (4 to 32ug/mL)
Imipenem/cilastatin	(0.5 to 16ug/mL) + Tobramycin (1 to 8ug/mL)
Imipenem/cilastatin	(0.5 to 16ug/mL) + Amikacin (4 to 32ug/mL) Aztreonam (2 to 16ug/mL) + Tobramycin (1 to 8ug/mL)

*Range of MICs tested shown in parentheses. Source:Saiman L, Niu WW, Prince A, et al: A referral center to study multi-resistant Pseudomonas aeruginosa. Pediatr Pulmonol S6:279, 1991.